Hotels in Southeast Missouri

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Tonight
May 16 - May 17
Tomorrow
May 17 - May 18
This weekend
May 16 - May 18
Next weekend
May 23 - May 25

Where to stay in Southeast Missouri?

OYO Malden Airport Inn
Reception

OYO Malden Airport Inn

2.5 star property
8.0 out of 10, Very Good, (43)
$52 nightly
The price is $57
May 21 - May 22
Total includes taxes and fees
OYO Malden Airport Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:May 23 - May 25

Image gallery for Microtel Inn & Suites by Wyndham Sainte Genevieve

Room, 2 Queen Beds, Non Smoking | Premium bedding, individually furnished, desk, laptop workspace

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
Ste Genevieve
8.8/10Excellent (565 reviews)
15% off
Price is $214
$96 nightly
$214 total
Total includes taxes and fees
Microtel Inn & Suites by Wyndham Sainte Genevieve

Top landmarks in Southeast Missouri

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

Elephant Rocks State Park is 5.3 mi (8.5 km) from central Ironton, why not stop by during your stay.

See properties in Elephant Rocks State Park
Elephant Rocks State Park

Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants, and sights like Lake Wappapello State Park and Clearwater Lake.

See all hotels in Southeast Missouri
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What accommodations do travelers recommend in Southeast Missouri?
Echo Bluff State Park, Hampton Inn Cape Girardeau I 55 East and Hampton Inn Poplar Bluff are all properties that our guests really like.
Can I book a refundable accommodation in Southeast Missouri?
If you need the flexibility to change your travel plans to Southeast Missouri, most hotels provide refundable* rates you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Which Southeast Missouri hotels do our guests like for their great location?
Travelers like these properties for their convenient location: Auburn Place Hotel And Suites, Pear Tree Inn Cape Girardeau Near the Medical Center and Courtyard by Marriott Cape Girardeau Downtown.
Where can I stay in Southeast Missouri if I want a cheap accommodation?
Auburn Place Hotel And Suites, Pear Tree Inn Cape Girardeau Near the Medical Center and Candlewood Suites Cape Girardeau, an IHG Hotel are a few accommodations you might want to consider that’ll save you money. You may want to browse more choices on our site, including 21 motels.
Where can I stay in Southeast Missouri if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, look over our selection of 129 vacation homes. In addition, there are 46 apartments and 7 condos.
Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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