Hotels near Mayo Clinic Florida Jacksonville

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Tonight
May 17 - May 18
Tomorrow
May 18 - May 19
Next weekend
May 23 - May 25
In two weeks
May 30 - Jun 1

Where to stay near Mayo Clinic Florida?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Reception

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
9.4 out of 10, Exceptional, (381)
$175 nightly
The price is $199
Jun 6 - Jun 7
Total includes taxes and fees
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other landmarks in Southside

Adventure Landing featuring landscape views and a waterpark

Adventure Landing

If thrills are what you're after, head to Adventure Landing, located 1 mi (1.7 km) from central Jacksonville Beach. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. If you have fun at Adventure Landing, you'll love Oceanfront Park, located nearby.

See properties in Adventure Landing
Adventure Landing
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What are the best hotels near Mayo Clinic Florida?
How much does it cost to stay in a hotel near Mayo Clinic Florida?
On Hotels.com, you can find a variety of room prices depending on when and where you plan to go. Simply sort by price on the search results and filter by your preferred criteria to find the best options for you and your budget.
  • Search for the lowest price per night $122 total
What cheap hotels are close to Mayo Clinic Florida?
Can I find hotels close to Mayo Clinic Florida that are fully refundable?
Yes, you’ll find hotels with refundable room rates, but be sure to check the cancellation deadline before you book. To find refundable rates, use the “Fully refundable” filter when you search for hotels.
What are the best romantic hotels near Mayo Clinic Florida?
What are the best hotels close to Mayo Clinic Florida with free breakfast?
Which hotels near Mayo Clinic Florida have rooms with great views?
What are the best family hotels close to Mayo Clinic Florida?
What are the best luxury hotels near Mayo Clinic Florida?
What are the best hotels near Mayo Clinic Florida with free parking?
What are the best hotels near Mayo Clinic Florida with a pool?
What cheap motels can I book close to Mayo Clinic Florida?
  • To save on your stay near Mayo Clinic Florida, take a look at Salt Air Inn & Suites, which offers an outdoor pool and a free local cuisine breakfast.
  • Another affordable motel to consider is San Marco Inn East.
What are the best things to see and do around my hotel near Mayo Clinic Florida?
  • While you’re here to visit Mayo Clinic Florida, you may also want to see top attractions like St. Johns Town Center and EverBank Stadium.
  • Other places in the area are Jacksonville Zoo and Gardens, World Golf Village, and Jacksonville Beach Pier.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

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