Photo by Jennifer Radman

Hotels in Des Peres

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Check prices for these dates

Tonight
May 11 - May 12
Tomorrow
May 12 - May 13
Next weekend
May 16 - May 18
In two weeks
May 23 - May 25

Where to stay in Des Peres?

Best Western St. Louis-Kirkwood Route 66
Lobby

Best Western St. Louis-Kirkwood Route 66

2.5 star property
8.6 out of 10, Excellent, (1146)
$104 nightly
The price is $121
May 18 - May 19
Total includes taxes and fees
Best Western St. Louis-Kirkwood Route 66
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Des Peres

Museum of Transportation

Museum of Transportation

Museum of Transportation is 2.5 mi (4 km) from central Des Peres, why not stop by during your stay. If you want to experience more of the culture Des Peres has to offer, head to Magic House - St. Louis Children's Museum, Missouri Baptist Medical Center, and Kirkwood Park.

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Museum of Transportation

Sugar Creek Park

Sugar Creek Park is worth a visit, located 1.8 mi (2.9 km) from central Des Peres. Our travelers also like the museums in the area— your cultural tour starts here.

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Sugar Creek Park

Learn more about Des Peres

Enterprise Center, St. Louis Zoo, and St. Louis Union Station are some of the top attractions around Des Peres.

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Museum of Transportation featuring interior views and signage
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What hotels do travelers like in Des Peres?
Guests like Clayton Plaza Hotel & Extended Stay, Sonesta ES Suites St. Louis - Chesterfield and Best Western St. Louis-Kirkwood Route 66.
Can I book refundable hotels in Des Peres?
If you need the flexibility to change your plans to Des Peres, most accommodations offer refundable* rates you can book. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Des Peres be like during my trip?
The warmest months in Des Peres are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 37°F. The rainiest months are May and April.
Why should I book my Des Peres accommodation with Hotels.com?
There are plenty of reasons to book your Des Peres travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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