Hotels in Santee

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Check prices for these dates

Tonight
May 10 - May 11
Tomorrow
May 11 - May 12
Next weekend
May 16 - May 18
In two weeks
May 23 - May 25

Where to stay in Santee?

Hampton Inn Santee-I-95
Seasonal outdoor pool

Hampton Inn Santee-I-95

2.5 star property
9.6 out of 10, Exceptional, (1000)
$136 nightly
The price is $151
May 26 - May 27
Total includes taxes and fees
Hampton Inn Santee-I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Santee are cheapest in February

See average prices and weather for all months

Price trends for hotels in Santee

Pricing is based on two traveler single night rates
May
$132
Average price during May is $132
Jun
$134
Average price during June is $134
Jul
$128
Average price during July is $128
Aug
$132
Average price during August is $132
Sep
$129
Average price during September is $129
Oct
$133
Average price during October is $133
Nov
$140
Average price during November is $140
Dec
$123
Average price during December is $123
Jan
$114
Average price during January is $114
Feb
$111
Average price during February is $111
Mar
$113
Average price during March is $113
Apr
$126
Average price during April is $126
Currently viewing crowd sizes and weather for May.

May

trending_flatModerate crowds
High 82°F / low 63°F. Sunny most days.
82°
weather_sun
May, Moderate crowds, average high temperature 82 degrees Fahrenheit, average low temperature 63 degrees Fahrenheit. Sunny most days.
63°
88°
weather_sun
June, Moderate crowds, average high temperature 88 degrees Fahrenheit, average low temperature 70 degrees Fahrenheit. Sunny most days.
70°
91°
weather_sun
July, Moderate crowds, average high temperature 91 degrees Fahrenheit, average low temperature 73 degrees Fahrenheit. Sunny most days.
73°
89°
weather_sun
August, Low crowds, average high temperature 89 degrees Fahrenheit, average low temperature 73 degrees Fahrenheit. Sunny most days.
73°
85°
weather_sun
September, Low crowds, average high temperature 85 degrees Fahrenheit, average low temperature 68 degrees Fahrenheit. Sunny most days.
68°
76°
weather_sun
October, High crowds, average high temperature 76 degrees Fahrenheit, average low temperature 58 degrees Fahrenheit. Sunny most days.
58°
65°
weather_sun
November, High crowds, average high temperature 65 degrees Fahrenheit, average low temperature 48 degrees Fahrenheit. Sunny most days.
48°
59°
weather_sun
December, High crowds, average high temperature 59 degrees Fahrenheit, average low temperature 44 degrees Fahrenheit. Sunny most days.
44°
56°
weather_sun
January, Low crowds, average high temperature 56 degrees Fahrenheit, average low temperature 40 degrees Fahrenheit. Sunny most days.
40°
61°
weather_sun
February, Low crowds, average high temperature 61 degrees Fahrenheit, average low temperature 43 degrees Fahrenheit. Sunny most days.
43°
67°
weather_sun
March, High crowds, average high temperature 67 degrees Fahrenheit, average low temperature 48 degrees Fahrenheit. Sunny most days.
48°
74°
weather_sun
April, Moderate crowds, average high temperature 74 degrees Fahrenheit, average low temperature 55 degrees Fahrenheit. Sunny most days.
55°
Monthly weather averages (˚F)
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Top landmarks in Santee

Santee State Park

Santee State Park is 2.7 mi (4.4 km) from central Santee, why not stop by during your stay.

See properties in Santee State Park
Santee State Park

Learn more about Santee

Notable for its golfing, Santee features attractions such as Santee Cooper Country Club and Santee Outlets. Visitors to this welcoming city speak highly of the restaurants whereas sights include Santee State Park and Santee National Golf Club.

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A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What accommodations do travelers like in Santee?
Fairfield Inn & Suites by Marriott Santee, Hampton Inn Santee-I-95 and Holiday Inn Santee by IHG are all accommodations that are popular with guests.
Where can I find free parking with my stay in Santee?
Park your car for free at these properties: Econo Lodge, Red Roof Inn Santee and Fairfield Inn & Suites by Marriott Santee. There are 10 options you may want to check out on our site.
Can I book refundable accommodations in Santee?
If you want the flexibility to change your plans to Santee, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay with my pet in Santee?
Your furry friend can stay with you at these pet-friendly hotels: Baymont by Wyndham Santee, Quality Inn & Suites and Tru By Hilton Santee. There are 11 options to choose from on our site.
Which Santee hotels do travelers like for their central location?
Our guests love Baymont by Wyndham Santee for its great location.
Where should I stay in Santee if I'm looking for a reasonably priced accommodation?
A few inexpensive options worth considering are Baymont by Wyndham Santee, Tru By Hilton Santee and Comfort Inn & Suites Santee.
Where can I stay in Santee if I want a vacation rental instead of a hotel?
Browse 9 vacation homes on our site. You also might want to book one of 83 condos for your trip.
Where can I stay if I'm traveling to Santee for a family-friendly trip?
Your kids are welcome at Comfort Inn & Suites Santee and Fairfield Inn & Suites by Marriott Santee.
What will the weather in Santee be like during my vacation?
July and August are typically the warmest months in Santee when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.
Why should I book my Santee hotel with Hotels.com?
There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

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