Hotels in Guadalupe

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Check prices for these dates

Tonight
May 15 - May 16
Tomorrow
May 16 - May 17
This weekend
May 16 - May 18
Next weekend
May 23 - May 25

Where to stay in Guadalupe?

Learn more about Guadalupe

You can explore the area's natural beauty at Malpelo Fauna and Flora Sanctuary during your stay.

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A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

Can I book a refundable hotel in Guadalupe?
If you want the flexibility to change your plans to Guadalupe, most accommodations provide refundable* rates you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Guadalupe be like during my visit?
September and January are typically the warmest months in Guadalupe when the average temp is 60°F. January and February are the coldest months when the average temperature is 59°F. May and April are the months with the most rain.
Why should I book my Guadalupe hotel with Hotels.com?
There are lots of reasons to book your Guadalupe trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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