Hotels in Wickliffe

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Tonight
May 11 - May 12
Tomorrow
May 12 - May 13
Next weekend
May 16 - May 18
In two weeks
May 23 - May 25

Where to stay in Wickliffe?

Quality Inn Cairo I-57
Lobby

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (250)
$69 nightly
The price is $76
Jun 9 - Jun 10
Total includes taxes and fees
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Wickliffe

Wickliffe is well-known for its attractions such as Mississippi River and Ohio River.

See all hotels in Wickliffe
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What accommodations do travelers recommend in Wickliffe?
Guests like Quality Inn Cairo I-57, La Center Motel and Victorian Splendor in So. Illinois: wallmanor.com.
Can I book a refundable accommodation in Wickliffe?
If you want the flexibility to change your plans to Wickliffe, most hotels provide refundable* bookable rates. You can see these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Wickliffe be like during my trip?
July and August are typically the warmest months in Wickliffe when the average temp is 76°F. January and February are the coldest months when the average temperature is 41°F. April and March are the months with the most rain.
Why should I book my Wickliffe hotel with Hotels.com?
There are lots of reasons to book your Wickliffe trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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